NA Proactive news snapshot: CytoDyn, New Pacific Metals, InnoCan Pharma, BioLargo UPDATE ...

CytoDyn Inc (OTCMKTS:CYDY) announced that it has filed for Breakthrough Therapy designation with the US Food and Drug Administration (FDA) for the use of its lead drug leronlimab as an adjuvant therapy for the treatment of metastatic triple-negative breast cancer (mTNBC). The filing is based on positive data from a patient in a mTNBC Phase 1b/2 trial and a second with metastatic stage 4 breast cancer enrolled in the trial under an emergency use investigational new drug (IND) process. CytoDyn said data from the first patient enrolled show no detectable circulating tumor cells (CTC) in the peripheral blood and additional reductions in CCR5 expression on cancer-associated cells at 11 weeks. CytoDyn CEO Nader Pourhassan noted that in the early stages of these clinical trials, the company was seeing “remarkable improvements” in patients living with metastatic breast cancer. New Pacific Metals Corp (CVE:NUAG) (OTCMKTS:NUMPF) reported positive new results from its 6,000 metre drill program at the Snake Hole prospect on its flagship Silver Sand project in Bolivia. On Monday, the Vancouver-based junior said that 15 of the 19 holes drilled on the prospect returned results that outlined structurally controlled, sandstone-hosted silver mineralization. Highlights of the results included 72.4 metres at 279 grams per ton silver from 60.5 metres to 132.9 metres, including nearly 33 metres at 517 grams per ton silver. InnoCan Pharma Corporation (CSE:INNO) announced Monday that it has achieved positive results following months of tests on its cannabidiol (CBD) loaded liposomal platform technology. The platform enables the delivery of cannabinoids by injection of hydrogel-cannabinoid-loaded liposomes into the bloodstream or to a specific body part, the Israeli cannabis company said in a statement. The controlled release of CBD (or other cannabinoids) from the liposomes may allow continuous exposure of the patient to the cannabinoid and decreases the variations of CBD concentration in the blood caused by food intake or other physiological conditions. High loading of CBD in an amount sufficient for administration of a therapeutic dose was achieved. BioLargo Inc (OTCMKTS:BLGO) announced Monday that it has set new quarterly and annual revenue records for 2019, thanks in part to growth in the company’s Odor-No-More subsidiary. In addition, CEO Dennis Calvert said the California-based environmental engineering company plans to tap more markets and customers heading into 2020, predicting at least a doubling of quarterly revenue. “We have only scratched the surface of our future potential,” he said in a statement. BioLargo said it pulled in more than $560,000 in revenue in the fourth quarter ended December 31, illustrating how the company has been steadily increasing its revenue figures. In the 3Q, the company brought in $534,000 -- a 93% year-over-year increase. Moreover, the company said revenue for the calendar year grew 37% year-over-year to more than $1.8 million, noting that it increased revenues over the past two years by 10% per quarter and generated positive cash flow for the Odor-No-More unit. Orgenesis Inc (NASDAQ:ORGS), a developer of advanced cell therapies, said Monday that it appointed industry veteran Mario Philips to the company’s board. Philips is the boss of France-headquartered PolyNeuroS, which has developed a diagnostic platform technology for neurodegenerative diseases in combination with a therapy to cure motor neuron disease Amyotrophic lateral sclerosis (ALS) and Parkinson’s. CEO Vered Caplan said the industry leader will help the company pursue collaboration and in-licensing opportunities to speed the development, lower costs and accelerate the path to market for transformative and lifesaving cell and gene therapies. Maverix Metals Inc (TSE:MMX) (NYSE:MMX) is heading into 2020 with a new package of high value royalty assets and a US$12 million injection into its war chest. The Vancouver-based company acquired a portfolio of 25 precious metal royalties from Kinross Gold Corporation (TSE:K) (NYSE:KGC) assets in December in cash-and-share deal. As part of the transaction, certain royalties were subject to rights of first refusal, including a 2% net smelter return royalty held on the Hammond Reef project operated by Brett Resources Inc, a subsidiary of Agnico Eagle Mines Limited. Mirasol Resources Ltd (CVE:MRZ) (OTCMKTS:MRZLF), the project generator, unveiled an option deal to buy the Inca gold project from mining major Newmont Corporation (NYSE:NEM) (TSE:NGT), bolstering its portfolio in Chile. The 14,000 hectare property has good access and lies in region III of Chile, the firm said. Newmont's exploration to date has been limited to surface work and prospecting. It has five target areas, none of which have been drill tested. "This is an attractive transaction allowing Mirasol to acquire Inca Gold by exploring and drilling the property. If our exploration demonstrates the potential for a Newmont size target, the agreement will allow them to earn back 70% of the project by reimbursing our costs and investing in significant additional exploration expenditures," he added. Gevo Inc (NASDAQ:GEVO) announced that Wbox 2019-3 Ltd (Whitebox) has exchanged its 12% convertible senior secured notes for $14.4 million in new notes with a later maturity date. The original notes were due in March 2020, and the two parties reached an exchange and purchase agreement to push the maturity date back to December 31, 2020 or April 1, 2021. The new notes also accrue interest at a rate of 12% per month, with 8% payable in cash and 4% as interest payable in kind. Whitebox has the option to purchase up to an additional $7.1 million in new notes. VolitionRx Limited (NYSEAMERICAN:VNRX) has developed a new Nu.Q magnetic particle-based assay format, which offers a higher grade of analytical sensitivity.  As a result of this re-engineering and transition from a microtiter plate format, Volition now expects to see improved clinical performance in the studies it will carry out in the coming months.The Belgian company has developed easy-to-use blood-based cancer tests, which accurately diagnose a range of cancers. The diagnostic tests are based on the science of nucleosomics, which is the practice of identifying and measuring nucleosomes in the bloodstream or other bodily fluids to get an indication that a disease is present. Namaste Technologies Inc (CVE:N) (OTCMKTS:NXTTF) announced Monday that Choklat Inc, a craft chocolate manufacturer and chocolatier in which Namaste holds a 49% equity, has received a processing license from Health Canada to produce a line of chocolate bars, drink mixes and infused sugar. "Receiving the processing license from Health Canada is a significant achievement and milestone," said Choklat CEO Brad Churchill in a statement, noting that the partnership will leverage the extensive B2B sales channels that Namaste subsidiary CannMart Inc has built.  Zynerba Pharmaceuticals Inc (NASDAQ:ZYNE) has hit the enrollment target for a Phase 2 study of its CBD-based autism treatment Zygel. The 14-week study, known as BRIGHT, has enrolled 36 pediatric and adolescent patients with autism spectrum disorder (ASD) in Australia. The goal is to evaluate the efficacy and safety of Zygel in patients with autism, using measurements such as the Aberrant Behavior Checklist, the Parent Rated Anxiety Scale, Autism Impact Measure and others. Allot Ltd (NASDAQ:ALLT), the security and smart network intelligence solutions company, said Monday that an undisclosed top mobile group operating in Central and Eastern Europe, has selected the Allot NetworkSecure Security-as-a-Service solution to protect its mobile users against cyber threats and offer a layer of parental control. With the help of Allot NetworkSecure, this company will be able to offer its customers the chance to protect their mobile devices from a range of cyberthreats, including malware, phishing, ransomware and crypto-jacking.  CROP Infrastructure Corp (CSE:CROP) (OTCMKTS:CRXPF) unveiled a sweeping proposed restructuring drive to divest itself of its underperforming assets, monetize its producing assets and “consolidate its share capital” to facilitate equity financing. CROP Infrastructure is focused on real estate assets and cannabis branding. The company name spells it out in a clear way: CROP is an acronym for Cannabis Real Estate Opportunity Portfolio, and it offers turnkey services by building, leasing and managing international cannabis and hemp infrastructure. Antibe Therapeutics Inc (CVE:ATE) (OTCMKTS:ATBPF) took another step towards commercializing its lead drug ATB-346 with the hiring of a new executive team member. Seasoned pharmaceutical executive Dr Rami Batal is joining the Toronto-based company as its new senior vice president, commercial strategy. With experience in pharmaceutical development and commercialization of pain drugs globally, Batal helped guide in-licensing on behalf of major pharma companies.  Millennial Lithium Corp (CVE:ML) (OTCQB:MLNLF) has increased its footprint at the flagship Pastos Grandes lithium project after the mining Court of Salta granted its Argentinian subsidiary four of the five mining licenses that comprised the original REMSA properties.  "Millennial is pleased to have received four of the mining licenses which comprise approximately 97% of the REMSA properties area of our Pastos Grandes project," the resource junior said in a statement. "The licenses granted total approximately 6,447 hectares (ha). Millennial expects the fifth license to be granted in the near future," it said. Great Panther Mining Limited (NYSEAMERICAN:GPL) (TSE:GPR) said its acquisition of the Tucano gold mine in Brazil last year nearly tripled the miner's gold equivalent production for 2019, as it posted full-year and fourth-quarter output figures. The metals miner generated around 147,000 consolidated gold equivalent ounces for the whole year -  a 182% increase on 2018. Acasti Pharma Inc (NASDAQ:ACST) (CVE:ACST) says further analysis is underway after topline results from its TRILOGY 1 trial for lead product CaPre did not reach statistical significance due to the unusually large placebo effect. The biotech is developing the krill-oil derived drug called CaPre to treat hypertriglyceridemia (high levels of triglycerides in the blood), which is known to contribute to heart disease and the findings of this Phase III trial have been much anticipated. eWellness Healthcare Corporation (OTCMKTS:EWLL), a provider of the state of the art PHZIO platform for the physical therapy (PT) and telehealth markets said it plans to launch by February 2020 a brand new Direct To Consumer PHZIO PT Treatments that include a Digital Advertising Program targeting individuals with back pain who are 30-50 years old. Ascent Industries Corp (CSE:ASNT) (OTCMKTS:PGTMF) announced after the close on Friday that CEO Paul Dillman has resigned from his position effective immediately to pursue other opportunities. Dillman is also leaving his position on the board of directors.  Newrange Gold Corp (CVE:NRG) (OTCMKTS:NRGOF) said it had brought in a total of C$1.5 million after it closed the second tranche of a placing for gross proceeds of C$495,000. The funds will be used to advance its flagship Pamlico gold project in Nevada, USA, for exploration at its newly-acquired Western Fold property in the Red Lake mining area of Ontario, Canada and for general working capital, it said in a statement.  Minera Alamos Inc. (CVE:MAI) has closed the private placement with Osisko Gold Royalties Ltd., announced on 6 December, 2019, consisting of 30,000,000 common shares in the company at a price of $0.20 each, raising aggregate gross proceeds of $6,000,000. It noted that, as a result of the offering, Osisko has increased its holding in the company’s common shares to 18.7% from 12.3%. Minera Alamos said it intends to use the net proceeds of the offering as a component of the capital funding required for building it’s Santana gold mine in Sonora, Mexico. Phunware (NASDAQ:PHUN), the provider of cloud platforms for mobile, has revealed that it filed a shelf registration statement on Form S-3 with the Securities and Exchange Commission on January 10. The Austin, Texas-based company provides a fully-integrated enterprise cloud platform for mobile that provides products, solutions, data and services for brands worldwide. Currently, the company has no plans to issue securities under the registration statement. However, Phunware is of the view that it’s prudent to file the shelf registration statement as a matter of standard corporate governance and to allow it to access the capital markets going forward.  Berkwood Resources Ltd (CVE:BKR) announced on Friday that the TSX Venture Exchange has accepted for filing documentation with respect to a discretionary waiver non-brokered private placement, announced on November 7, 2019, and December 13, 2019, which will see the company issue 5,172,000 shares at a price of 2.5 cents each, together with 5,172,000 share purchase warrants at an exercise price of five cents for a two-year period with 11 placees. Aftermath Silver Ltd (CVE:AAG) said on Friday that the TSX Venture Exchange has accepted for filing a share purchase agreement by the company and Mandalay Resources Corp., dated November 8, 2019, under which Aftermath will acquire all of the issued and outstanding shares of Minera Mandalay Challacollo Ltda., the holder of the Challacollo silver-gold project, located in Chile. As consideration, the company will pay $7.5million to the sellers, of which up to $2.75million may be paid in shares of the company, subject to the further approval of the exchange. The sellers will also receive a net smelter royalty (NSR) of 3% on the Challacollo silver-gold project up to a maximum of $3million. An arm's-length finder's fee of $407,500 is payable to Elysium Mining Ltd.