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Has the Aging Process Just Been Succesfully Reversed?

One News Page Staff Thursday, 2 August 2018
Has the Aging Process Just Been Succesfully Reversed?by 👨‍💻 Adam Yardley

"Unprecedented" DNA Discovery Reverses Wrinkles And Hair Loss in Mice

Who wants to live forever? It’s been a long time since Queen asked this question of us – but it’s still a pretty valid query! The aging process, at least – and the thought of being able to bathe in the fountain of youth – have been at the center of many a middle-aged person’s mind. It’s a fact of life that, as we get older, we develop wrinkles in our skin, men may lose hair, we go grey… most of us have come to terms with the thought of physical aging. For those who may still be struggling with the idea of leaving their youth behind, however, it’s emerged that a scientific trial appears to have reversed typical signs of aging in mice under laboratory conditions. If such studies prove to have found strategies which could work in humans, we could be looking at a genuine revolution. Could it add a few years onto our lives at least?

It’s been reported via the latest edition of the journal Cell Death & Disease that researchers working at the University of Alabama, US, have been able to restore certain functions within rodents – therefore effectively reversing hair loss and wrinkle development. Keshav Singh, PhD, has been at the center of the study and has confirmed that through the use of an antibiotic known as doxycycline, they were able to mimic the aging process by recreating gene mutation brought on by mitochondrial decline. After creating the condition, the researchers were, amazingly, able to reverse the hair loss and wrinkle development experienced by the mice by eventually stopping the application of the antibiotic – and after this point, DNA affected by the mitochondrial factors began to repair itself. This news seems to suggest that the mitochondrial problems which lead to aging of the skin, hair and bodily functions could be reversed somehow.

Gene Editing Reversed Wrinkles And Balding In Mice, Humans May Be next
Gene Editing Reversed Wrinkles And Balding In Mice, Humans May Be next

“It suggests that epigenetic mechanisms underlying mitochondria-to-nucleus cross-talk must play an important role in the restoration of normal skin and hair phenotype,” Singh advised. “This mouse model should provide an unprecedented opportunity for the development of preventive and therapeutic drug development strategies to augment the mitochondrial functions for the treatment of aging-associated skin and hair pathology and other human diseases in which mitochondrial dysfunction plays a significant role.”

Could this mean that further studies may lead to the cure to aging, period? It’s too early to say – but stay tuned!


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