Charles walked passed Pence and then shook hands with Israeli Prime Minister Benjamin Netanyahu standing next to Pence during the memorial marking the 75th anniversary of the liberation of Auschwitz death and concentration camp .
Following his address at the forum, Pence shook hands with Prince Charles, clearing up speculations.
Russian President Vladimir Putin who arrived late for the ceremony shook hands with Prince Charles after taking his seat next to Israeli President Reuven Rivlin.
Israel has hailed the World Holocaust Forum at the Yad Vashem memorial centre as the biggest international gathering in its history.
It is being held against the backdrop of a rise in anti-Semitic attacks in the United States and Europe.
More than one million people, most of them Jews, were killed at the Auschwitz-Birkenau camp during World War Two.
Overall, some six million Jews died in the Holocaust.