Inflammation: Targeting the transporter

Using specially-developed nanobodies that bind to SPNS2 and enlarge the entire structure, the enlarged SPNS2 structure allows the S1P molecules to be viewed via cryogenic electron microscopy. Scientists have analyzed the structure of the SPNS2 protein at an atomic level that could provide greater insights into how S1P signalling molecules are released to communicate with the immune cells to regulate inflammatory responses.