Complement 3 Glomerulopathy Market to Witness an Upsurge in Growth by 2023, Predicts DelveInsight | Key Companies to Watch - Novartis, Apellis, NovelMed, Amyndas, Arrowhead
The dynamics of the complement 3 glomerulopathy market are anticipated to change in the coming years owing to the improvement in the research and development activities so that the complement 3 glomerulopathy market will comprise efficient treatment options. The launch of emerging therapies is expected during the forecast period of 2023-2032.
New York, USA, Nov. 06, 2023 (GLOBE NEWSWIRE) -- *Complement 3 Glomerulopathy Market to Witness an Upsurge in Growth by 2023, Predicts DelveInsight | Key Companies to Watch - Novartis, Apellis, NovelMed, Amyndas, Arrowhead*
*The dynamics of the complement 3 glomerulopathy market are anticipated to change in the coming years owing to the improvement in the research and development activities so that the complement 3 glomerulopathy market will comprise efficient treatment options. The launch of emerging therapies is expected during the forecast period of 2023-2032.*
DelveInsight’s *Complement 3 Glomerulopathy Market Insights* report includes a comprehensive understanding of current treatment practices, complement 3 glomerulopathy emerging drugs, market share of individual therapies, and current and forecasted complement 3 glomerulopathy market size from 2019 to 2032, segmented into 7MM [the United States, the EU-4 (Italy, Spain, France, and Germany), the United Kingdom, and Japan].
*Key Takeaways from the Complement 3 Glomerulopathy Market Report*
· As per DelveInsight’s analysis, the complement 3 glomerulopathy market size was found to be *USD 100 million* in 2022 in the 7MM and it is anticipated to grow at a significant CAGR by 2032.
· As per DelveInsight estimates, the total diagnosed prevalent population of C3G in the seven major markets was estimated to be *~8.3K* in 2022.
· Leading complement 3 glomerulopathy companies such as *Novartis Pharmaceuticals, Apellis Pharmaceuticals, NovelMed Therapeutics, Amyndas Pharmaceuticals, Arrowhead Pharmaceuticals, *and others are developing novel complement 3 glomerulopathy drugs that can be available in the complement 3 glomerulopathy market in the coming years.
· Some of the key therapies for complement 3 glomerulopathy treatment include *Iptacopan (LNP023), Pegcetacoplan (APL-2), NM8074, AMY101, ARO-C3**, *and others.
Discover which therapies are expected to grab the major complement 3 glomerulopathy market share @ *Complement 3 Glomerulopathy Market Report*
*Complement 3 Glomerulopathy Overview*
In 2013, experts reached a consensus on the term complement 3 glomerulopathy (C3G) to describe a cluster of rare kidney diseases primarily caused by dysregulation of the complement cascade. C3G falls under the category of glomerular diseases and is characterized by the predominant presence of C3 complement component (C3) deposits within the glomeruli. Importantly, these deposits occur without significant levels of immunoglobulin and without the deposition of C1q and C4. Dysregulation of the complement alternative pathway, attributed to acquired and/or genetic factors, plays a key role in the pathogenesis of C3G. However, it's worth noting that alternative pathway abnormalities are also observed in immune complex-mediated membranoproliferative glomerulonephritis (IC-MPGN). The most common acquired factors contributing to C3G are C3 nephritic factors (C3NeFs), which are a diverse group of autoantibodies that enhance the stability of the C3 convertase, known as C3bBb.
*Complement 3 Glomerulopathy Epidemiology Segmentation*
The complement 3 glomerulopathy epidemiology section provides insights into the historical and current complement 3 glomerulopathy patient pool and forecasted trends for the 7MM. It helps recognize the causes of current and forecasted trends by exploring numerous studies and views of key opinion leaders.
The *complement 3 glomerulopathy market report* proffers epidemiological analysis for the study period 2019–2032 in the 7MM segmented into:
· Total Complement 3 Glomerulopathy Diagnosed Prevalent Population
· Complement 3 Glomerulopathy Type-specific Diagnosed Prevalent Population
· Complement 3 Glomerulopathy Age-specific Diagnosed Prevalent Population
Download the report to understand which factors are driving complement 3 glomerulopathy epidemiology trends @ *Complement 3 Glomerulopathy Epidemiological Insights*
*Complement 3 Glomerulopathy Treatment Market *
The ideal treatment for C3G remains uncertain, as no specific therapy has demonstrated consistent effectiveness. Current recommendations primarily rely on case series and observational studies, supplemented by expert opinions. Consequently, treatment approaches are not standardized and often centralized in specialized centers. In general, all C3G-diagnosed patients should undergo renoprotective measures, which include lifestyle modifications and the administration of an angiotensin-converting enzyme inhibitor or angiotensin-receptor blocker to manage hypertension and proteinuria. Additionally, lipid-lowering medications are recommended. However, it’s important to note that these medications alone do not guarantee protection against progressing to end-stage renal disease but may enhance the effectiveness of immunosuppressive treatment.
While robust data on plasma therapy are lacking, some cases have reported favorable outcomes when a mutated protein is identified as a causal factor in the disease. Plasma therapy has shown promise in treating patients with C3 glomerulopathy who have acute kidney injury. However, it has not been successful in patients with C3 nephritic factors, likely due to ongoing autoantibody production. In one case, a patient with recurrent dense deposit disease (DDD) following a kidney transplant received thrice-weekly plasma exchanges, successfully removing circulating C3 nephritic factors. Unfortunately, when this treatment was discontinued, the allograft failed. This suggests that the precise role of plasma therapy in C3G patients is yet to be adequately defined.
Learn more about the FDA-approved drugs for complement 3 glomerulopathy @ *Drugs for* *Complement 3 Glomerulopathy Treatment** *
*Key Complement 3 Glomerulopathy Therapies and Companies*
· Iptacopan (LNP023): Novartis Pharmaceuticals
· Pegcetacoplan (APL-2): Apellis Pharmaceuticals
· NM8074: NovelMed Therapeutics
· AMY101: Amyndas Pharmaceuticals
· ARO-C3: Arrowhead Pharmaceuticals
To know more about complement 3 glomerulopathy clinical trials, visit @ *Complement 3 Glomerulopathy Treatment Drugs** *
*Complement 3 Glomerulopathy Market Dynamics*
The complement 3 glomerulopathy market dynamics are anticipated to change in the coming years. In the burgeoning C3G market, there are several notable contenders including *Apellis Pharmaceuticals, ChemoCentryx, and Novartis Pharmaceuticals*. The introduction of *innovative biomarkers* in the near future holds the potential to illuminate the disease’s pathophysiology, ultimately improving diagnosis. Numerous organizations, such as *WeC3G, the National Kidney Foundation (NKF), the American Society of Nephrology (ASN), the Kidney Disease: International Global Organization (KDIGO), the Japanese Society of Nephrology (JSN)*, and others, actively strive to disseminate information and *raise awareness* about this condition.
Furthermore, many potential therapies are being investigated for the treatment of complement 3 glomerulopathy, and it is safe to predict that the treatment space will significantly impact the complement 3 glomerulopathy market during the forecast period. Moreover, the *anticipated introduction of emerging therapies* with improved efficacy and a further *improvement in the diagnosis rate* are expected to drive the growth of the complement 3 glomerulopathy market in the 7MM.
However, several factors may impede the growth of the complement 3 glomerulopathy market. The clinical presentation of *ICGN and PIGN* shares significant similarities with that of C3G, posing a challenge in differentiating and *diagnosing C3G patients* promptly. Additionally, the* absence of reliable diagnostic tools* complicates the differential diagnosis of C3G. In cases where C3G progresses to end-stage kidney failure, patients are frequently advised to undergo* hemodialysis or kidney transplantation*. However, it’s important to note that renal transplantation is associated with a* high rate of disease recurrence* in the transplanted kidney, and approximately half of such transplants ultimately prove unsuccessful.
Moreover, complement 3 glomerulopathy treatment poses a *significant economic burden* and disrupts patients’ overall well-being and QOL. Furthermore, the complement 3 glomerulopathy market growth may be offset by *failures and discontinuation of emerging therapies*, *unaffordable pricing*, *market access and reimbursement issues*, and a *shortage of healthcare specialists*. In addition, the *undiagnosed, unreported cases and the unawareness* about the disease may also impact the complement 3 glomerulopathy market growth.
*Complement 3 Glomerulopathy Report Metrics* *Details*
Study Period 2019–2032
Complement 3 Glomerulopathy Report Coverage 7MM [The United States, the EU-4 (Germany, France, Italy, and Spain), the United Kingdom, and Japan]
Complement 3 Glomerulopathy Market Size in 2022 USD 100 Million
Key Complement 3 Glomerulopathy Companies Novartis Pharmaceuticals, Apellis Pharmaceuticals, NovelMed Therapeutics, Amyndas Pharmaceuticals, Arrowhead Pharmaceuticals, and others
Key Complement 3 Glomerulopathy Therapies Iptacopan (LNP023), Pegcetacoplan (APL-2), NM8074, AMY101, ARO-C3, and others
*Scope of the **Complement 3 Glomerulopathy** Market Report*
· *Therapeutic Assessment: *Complement 3 Glomerulopathy current marketed and emerging therapies
· *Complement 3 Glomerulopathy* *Market Dynamics:* Attribute Analysis of Emerging Complement 3 Glomerulopathy Drugs
· *Competitive Intelligence Analysis:* SWOT analysis and Market entry strategies
· *Unmet Needs, KOL’s views, Analyst’s views, Complement 3 Glomerulopathy Market Access and Reimbursement*
Discover more about complement 3 glomerulopathy drugs in development @ *Complement 3 Glomerulopathy Clinical Trials*
*Table of Contents*
1. Complement 3 Glomerulopathy Market Key Insights
2. Complement 3 Glomerulopathy Market Report Introduction
3. Complement 3 Glomerulopathy Market Overview at a Glance
4. Complement 3 Glomerulopathy Market Executive Summary
5. Disease Background and Overview
6. Complement 3 Glomerulopathy Treatment and Management
7. Complement 3 Glomerulopathy Epidemiology and Patient Population
8. Patient Journey
9. Complement 3 Glomerulopathy Marketed Drugs
10. Complement 3 Glomerulopathy Emerging Drugs
11. Seven Major Complement 3 Glomerulopathy Market Analysis
12. Complement 3 Glomerulopathy Market Outlook
13. Potential of Current and Emerging Therapies
14. KOL Views
15. Unmet Needs
16. SWOT Analysis
17. Appendix
18. DelveInsight Capabilities
19. Disclaimer
20. About DelveInsight
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