Medigene to Present at Upcoming Scientific Conferences

Medigene to Present at Upcoming Scientific Conferences



Medigene AG (Medigene or the “Company”, FSE: MDG1, Prime Standard), an immuno-oncology platform company focusing on the discovery and development of T cell immunotherapies for solid tumors, has been invited to present at the CHI's 8^th Annual Immuno-Oncology Summit Europe from April 23-25, 2024, in London, UK, as well as at the 7^th International Neoantigen Summit to be held in Amsterdam, Netherlands from April 29 - May 1, 2024.

The presentations will be available on Medigene´s website after the conferences:

*Oral presentation:*

*CHI's 8th Annual Immuno-Oncology Summit Europe 2024
Location: Hilton London Canary Wharf, London
Date and time: April 25, 2024, 13:15 – 13:45 pm local time
Presenter: Kirsty Crame, MD, VP Clinical Strategy & Development
Session: Novel approaches targeting solid tumors
Title: *Medigene's MDG1015, a Third-Generation TCR-T Therapy Incorporating the PD1-41BB Costimulatory Switch Protein, Advancing to the Clinic*

The work to be presented will highlight the Company’s lead candidate MDG1015, a first-in-class, third generation T cell receptor engineered T cell (TCR-T) therapy targeting NY-ESO-1/ LAGE-1a (New York oesophageal squamous cell carcinoma 1 / L Antigen Family Member-1a), armored and enhanced with the PD1-41BB costimulatory switch protein (CSP). A first-in-human trial for MDG1015 is planned for gastric cancer, ovarian cancer, myxoid/round cell liposarcoma and synovial sarcoma with IND/CTA filing targeted for 2H 2024.

*Oral presentation:*

*7th International Neoantigen Summit 2024
Location: Hotel Novotel Amsterdam City, Amsterdam*
*Date and time: May 1, 2024, 12:00 – 12:30 pm local time
Presenter: Dr. Giulia Longinotti, Director TCR Discovery Platform
Session: Illuminating Shared Neoantigen Therapies to Induce More Durable & Robust Immunity in a Larger Patient Population
Title: *KRAS Mutation-Specific TCR-T Cells are Empowered for Improved Multi-Functionality & Durability by Inclusion of a Costimulatory Switch Protein*

Dr. Longinotti will summarize the generation process of optimal affinity 3S (sensitive, specific and safe) TCRs targeting various Kirsten rat sarcoma virus specific mutations (mKRAS), armored and enhanced with the PD1-41BB CSP. In vitro data will showcase how armoring tools such as the PD1-41BB CSP can enhance TCR-T cell functionality, and will also illustrate how the composition of the drug product can be optimized for safety, efficacy and durability.

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*About Medigene AG*

Medigene AG (FSE: MDG1) is an immuno-oncology platform company dedicated to developing differentiated T cell therapies for treatment of solid tumors. Its End-to-End Platform is built on multiple proprietary and exclusive technologies that enable the Company to generate optimal T cell receptors against both cancer testis antigens and neoantigens, armor and enhance these T cell receptor engineered (TCR) -T cells to create best-in-class, differentiated TCR-T therapies, and optimize the drug product composition for safety, efficacy and durability. The End-to-End Platform provides product candidates for both its own therapeutics pipeline and partnering. Medigene’s lead TCR-T program MDG1015 is expected to receive IND/CTA approval in the second half of 2024. For more information, please visit. For more information, please visit

This press release contains forward-looking statements representing the opinion of Medigene as of the date of this release. The actual results achieved by Medigene may differ significantly from the forward-looking statements made herein. Medigene is not bound to update any of these forward-looking statements. Medigene^® is a registered trademark of Medigene AG. This trademark may be owned or licensed in select locations only.

*Medigene AG*

Pamela Keck
Phone: +49 89 2000 3333 01

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