The actor says although he didn't have symptoms as bad as Wilson, he felt "wiped" while in isolation at a hospital in Queensland, Australia last month.
I laid down in my hospital bed and just slept," Hanks told National Defense Radio Show.
He said that his wife had such bad nausea from the anti-malaria drug hydroxychloroquine, that at times she couldn't even walk.
"Rita went through a tougher time than I did," Hanks went on to say.
"She had a much higher fever and she had some other symptoms.